Loperamide hydrochloride

Name: Loperamide hydrochloride
Brand: Tocris Bioscience
SKU: 0840

Catalog # 0840

Citations (1)

COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	Peripherally acting μ agonist; Ca²⁺ channel blocker
Chemical Name:	4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	513.51

View Full Technical Details for Loperamide hydrochloride

Complete Your Research

Biological Activity

Loperamide hydrochloride is a high affinity μ-opioid receptor agonist with peripheral selectivity (K_i values are 2, 48 and 1156 nM for μ-, δ- and κ-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca²⁺ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca²⁺ channels and at higher concentrations it reduces Ca²⁺ flux through NMDA receptor operated channels. Inhbits replication of MERS-CoV and SARS-CoV in vitro.

Technical Data

M. Wt	513.51
Formula	C₂₉H₃₃ClN₂O₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	34552-83-5
PubChem ID	71420
InChi Key	PGYPOBZJRVSMDS-UHFFFAOYSA-N
Smiles	Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	10.27	20
	DMSO	10.27	20

Preparing Stock Solutions

The following data is based on the product molecular weight 513.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.74 mL	48.68 mL	97.37 mL
1 mM	1.95 mL	9.74 mL	19.47 mL
2 mM	0.97 mL	4.87 mL	9.74 mL
10 mM	0.19 mL	0.97 mL	1.95 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

de Wilde Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East Respiratory Syndrome coronavirus replication in cell culture. Antimicrob.Agents.Chemother.
Dehaven-Hudkins Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J.Pharmacol.Exp.Ther. 1999 PMID: 10087042
Daly Maitotoxin-elicited calcium influx in cultured cells - effect of calcium channel block. Biochem.Pharmacol. 1995 PMID: 7488233
Church Loperamide blocks high-voltage activated calcium channels and N-MthD.-aspartate -evoked responses in rat and mouse cultured hippocampal pyramidal neurons. Mol.Pharmacol. 1994 PMID: 8183255
Awouters Pharmacology of antidiarrheal drugs. Annu.Rev.Pharmacol.Toxicol. 1983 PMID: 6307123

Citations for Loperamide hydrochloride (1)

Showing 1 - 1 of 1 citation Showing All

View all citations for the Small Molecules and Peptides platform.

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Loperamide hydrochloride include:

Sałaga et al. (2015) Calea zacatechichi dichloromethane extract exhibits antidiarrheal and antinociceptive effects in mouse models mimicking irritable bowel syndrome. J Pharmacol Exp Ther. 388:1069
PMID: 26068703

There are no citations that match your criteria.