LG 101506

Name: LG 101506
Brand: Tocris Bioscience
SKU: 3508

Catalog # 3508 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Selective RXR modulator

Key Product Details

Description:	Selective RXR modulator
Alternative Names:	LG 1506
Chemical Name:	(2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	420.53

View Full Technical Details for LG 101506

Technical Data
Citations (1) / Reviews

Biological Activity for LG 101506

LG 101506 is a selective RXR modulator (K_i values are 3, 9 and 11 nM for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (K_i values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.

Technical Data for LG 101506

M. Wt	420.53
Formula	C₂₅H₃₄F₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	331248-11-4
PubChem ID	9845057
InChi Key	BHIBZAZKKARFIM-XRYBSMBUSA-N
Smiles	CC(C)(C)C1=CC(/C(C)=C\C=C\C(C)=C\C(O)=O)=C(OCC(F)F)C(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LG 101506

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.05	100
	ethanol	21.03	50

Preparing Stock Solutions for LG 101506

The following data is based on the product molecular weight 420.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.89 mL	23.78 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for LG 101506

References are publications that support the biological activity of the product.

Pinaire Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome. PPAR Res. 2007 PMID: 17497022
Leibowitz Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology 2006 PMID: 16269450
Michellys Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J.Med.Chem. 2003 PMID: 12801232

Citations for LG 101506 (1)

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Citations are publications that use Bio-Techne products. Selected citations for LG 101506 include:

Ronn et al. (2015) Retinoic Acid regulates hematopoietic development from human pluripotent stem cells. Development. 4:269
PMID: 25680478

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