LDN 209929 dihydrochloride

Name: LDN 209929 dihydrochloride
Brand: Tocris Bioscience
SKU: 4828

Tocris Bioscience a Bio-Techne Brand

Catalog # 4828

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Key Product Details

Description:	Potent and selective haspin inhibitor
Chemical Name:	3-[(2-Chloro-7-methoxy-9-acridinyl)thio]-1-propanamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	405.77

View Full Technical Details for LDN 209929 dihydrochloride

Biological Activity for LDN 209929 dihydrochloride

LDN 209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC₅₀ = 55 nM). Displays 180-fold selectivity over DYRK2.

Technical Data for LDN 209929 dihydrochloride

M. Wt	405.77
Formula	C₁₇H₁₇ClN₂OS.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1784281-97-5
PubChem ID	90488975
InChi Key	WOCCOXNODBCCGK-UHFFFAOYSA-N
Smiles	ClC1=CC=C(N=C(C=CC(OC)=C3)C3=C2SCCCN)C2=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LDN 209929 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	40.58	100
	DMSO	40.58	100

Preparing Stock Solutions for LDN 209929 dihydrochloride

The following data is based on the product molecular weight 405.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.32 mL	24.64 mL
5 mM	0.49 mL	2.46 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for LDN 209929 dihydrochloride

References are publications that support the biological activity of the product.

Cuny Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg.Med.Chem.Lett. 2010 PMID: 20836251

Citations for LDN 209929 dihydrochloride

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