L-755,507

Name: L-755,507
Brand: Tocris Bioscience
SKU: 2197
Price: 219 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 2197

Citations (6)

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Key Product Details

Description:	Very potent and selective β₃ partial agonist
Chemical Name:	4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	584.73

View Full Technical Details for L-755,507

Biological Activity for L-755,507

L-755,507 is a potent β₃-adrenergic receptor partial agonist > 1000-fold selective over β₁- and β₂-adrenoceptors (EC₅₀ values are 0.43, 580 and > 10000 nM for activation of cloned human β₃-, β₁- and β₂-adrenoceptors respectively). Stimulates lipolysis in rhesus adipocytes in vitro (EC₅₀ = 3.9 nM). Enhances CRISPR-mediated homology-directed repair (HDR) efficiency 2-3-fold for large fragments and ~9-fold for point mutations, in human induced pluripotent stem cells (iPSCs).

Compound Libraries for L-755,507

L-755,507 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-755,507

M. Wt	584.73
Formula	C₃₀H₄₀N₄O₆S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	159182-43-1
PubChem ID	9829836
InChi Key	NYYJKMXNVNFOFQ-MHZLTWQESA-N
Smiles	O=S(C1=CC=C(NC(NCCCCCC)=O)C=C1)(NC2=CC=C(CCNC[C@H](O)COC3=CC=C(O)C=C3)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-755,507

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	58.47	100
	ethanol	58.47	100

Preparing Stock Solutions for L-755,507

The following data is based on the product molecular weight 584.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.71 mL	8.55 mL	17.10 mL
5 mM	0.34 mL	1.71 mL	3.42 mL
10 mM	0.17 mL	0.86 mL	1.71 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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References for L-755,507

References are publications that support the biological activity of the product.

Yu Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 2015 PMID: 25658371
Parmee Discovery of L-755,507: a subnanomolar human β₃ adrenergic receptor agonist. Bioorg.Med.Chem.Lett. 1998 PMID: 9871717
Fisher A selective human β₃ adrenergic receptor agonist increases metabolic rate in rhesus monkeys. J.Clin.Invest. 1998 PMID: 9616210

Citations for L-755,507 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for L-755,507 include:

Riesenberg and Maricic (2018) Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells. Nat Commun. 9:2164
PMID: 29867139
Kornete et al. (2018) Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells. J Immunol. 200:2489
PMID: 29445007
Pinder et al. (2015) Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing. Nucleic Acids Res. 43:9379
PMID: 26429972
Afeli et al. (2012) Do β3-adrenergic receptors play a role in guinea pig detrusor smooth muscle excitability and contractility?. Am J Physiol Renal Physiol. 302:F251
PMID: 21993887
Coan et al. (2009) Promiscuous aggregate-based inhibitors promote enzyme unfolding. J Med Chem. 52:2067
PMID: 19281222
Coan and Shoichet (2008) Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors. J Am Chem Soc. 130:9606
PMID: 18588298

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Showing 1 - 6 of 6 citations Showing All

Product Documents for L-755,507

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.