L-689,560
Tocris Bioscience, part of Bio-Techne | Catalog # 0742
Highly potent NMDA antagonist
Product Description
L-689,560 is a very potent antagonist at the glycine-NMDA site.Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.Product Specifications
Molecular Weight
380.23
Formula
C17H15Cl2N3O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
CAS Number
139051-78-8
PubChem ID
6604749
InChI Key
UCKHICKHGAOGAP-UONOGXRCSA-N
SMILES
ClC1=C2C(N[C@@H]([C@](O)=O)C[C@@H]2NC(NC3=CC=CC=C3)=O)=CC(Cl)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.51 | 25 | |
| Ethanol | 38.02 | 100 |
Preparing Stock Solutions
for L-689,560
The following data is based on the product molecular weight 380.23
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.15 mL | 26.30 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Stone Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 2000 PMID: 10740291
- Leeson trans-2-Carboxy-4-substituted tetrahydroquinolines. Potent glycine-site NMDA receptor antagonists. Med.Chem.Res.
- Leeson 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationship for antagonism at the glycine site of the NMDA receptor. J.Med.Chem. 1992 PMID: 1534584
Product Specific Notices for L-689,560
For research use only
Loading...
Loading...