L-364,373

Name: L-364,373
Brand: Tocris Bioscience
SKU: 2660
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2660

(1)

Citations (4)

COA / SDS

KV7.1 channel activator, activates IKs

Discontinued Product

2660 has been discontinued. View all Voltage-gated Potassium Channel Activators products.

Key Product Details

Description:	K_V7.1 channel activator, activates I_Ks
Alternative Names:	R-L3
Chemical Name:	5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	397.44

View Full Technical Details for L-364,373

Technical Data
Citations / Reviews (1)

Biological Activity for L-364,373

L-364,373 is an activator of K_V7.1 (KCNQ1) channels. Activates the cardiac I_Ks current that decreases action potential duration (APD) in cardiac myocytes.

Technical Data for L-364,373

M. Wt	397.44
Formula	C₂₅H₂₀FN₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	103342-82-1
PubChem ID	656755
InChi Key	CGBANSGENFERAT-JOCHJYFZSA-N
Smiles	CN(C1=CC=CC=C1C(C5=CC=CC=C5F)=N[C@@H]2CC3=CNC4=C3C=CC=C4)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for L-364,373

References are publications that support the biological activity of the product.

Chadha Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 2012 PMID: 22251082
Jow Rb⁺ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 2006 PMID: 16945016
Salata A novel benzodiazepine that activates cardiac slow delayed rectifier K⁺ currents. Am.Soc.Pharmacol.Exp.Ther.
Seebohm Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 2003 PMID: 14576198

L-364,373

Tocris Bioscience, part of Bio-Techne | Catalog # 2660

Key Product Details

Biological Activity for L-364,373

Technical Data for L-364,373

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for L-364,373

Product Documents for L-364,373

COA

Certificate of Analysis

SDS

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