KYA 1797K

Name: KYA 1797K
Brand: Tocris Bioscience
SKU: 7002

Tocris Bioscience, part of Bio-Techne | Catalog # 7002

Citations (1)

COA / SDS

Wnt/β-catenin signaling inhibitor

Discontinued Product

7002 has been discontinued. View all beta-Catenin Compounds products.

Key Product Details

Description:	Wnt/β-catenin signaling inhibitor
Chemical Name:	(5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
Purity:	≥98% (HPLC)
Molecular Weight:	442.5

View Full Technical Details for KYA 1797K

Technical Data
Citations

Biological Activity for KYA 1797K

KYA 1797K is a Wnt/β-catenin signaling inhibitor (IC₅₀ = 0.75 μM). Increases binding affinity of β-catenin for axin, GSK-3β and β-TrCP. Promotes formation of the destruction complex, activation of GSK-3β and phosphorylation of β-catenin and K-Ras, leading to their degradation via the ubiquitin/proteasome system. Reduces levels of β-catenin and K-Ras and inhibits growth of colorectal cancer (CRC) cells in vitro and in mouse xenograft models.

Technical Data for KYA 1797K

M. Wt	442.5
Formula	C₁₇H₁₁KN₂O₆S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1956356-56-1
PubChem ID	119057297
InChi Key	PHUNRLYHXGMOLG-WQRRWHLMSA-M
Smiles	C1=CC(=CC=C1C2=CC=C(O2)/C=C\3/C(=O)N(C(=S)S3)CCC(=O)[O-])[N+](=O)[O-].[K+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for KYA 1797K

References are publications that support the biological activity of the product.

Park A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer. Sci.Rep. 2019 PMID: 30679620
Cha Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat.Chem.Biol. 2016 PMID: 27294323

KYA 1797K

Tocris Bioscience, part of Bio-Techne | Catalog # 7002

Key Product Details

Biological Activity for KYA 1797K

Technical Data for KYA 1797K

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for KYA 1797K

Product Documents for KYA 1797K

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected