JWH 018

Name: JWH 018
Brand: Tocris Bioscience
SKU: 1342

Tocris Bioscience a Bio-Techne Brand

Catalog # 1342

Citations (1)

COA / SDS

Discontinued Product

1342 has been discontinued. View all Non-selective Cannabinoid Receptor Agonists products.

Key Product Details

Description:	Potent CB₁ and CB₂ agonist
Chemical Name:	(1-Pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
Purity:	≥99% (HPLC)
Molecular Weight:	341.45

View Full Technical Details for JWH 018

Biological Activity for JWH 018

Potent cannabinoid receptor agonist with mild selectivity for CB₂ (K_i values are 2.94 and 9.0 nM for CB₂ and CB₁ receptors respectively).

Technical Data for JWH 018

M. Wt	341.45
Formula	C₂₄H₂₃NO
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	209414-07-3
PubChem ID	10382701
InChi Key	JDNLPKCAXICMBW-UHFFFAOYSA-N
Smiles	O=C(C3=CN(CCCCC)C4=C3C=CC=C4)C1=CC=CC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for JWH 018

References are publications that support the biological activity of the product.

Huffman 3-Indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB₁ cannabinoid receptor. Bioorg.Med.Chem. 2003 PMID: 12538019
Aung Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. Drug Alcohol Depend. 2000 PMID: 10940540
Chin The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J.Pharmacol.Exp.Ther. 1999 PMID: 10525107

Citations for JWH 018 (1)

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Citations are publications that use Bio-Techne products. Selected citations for JWH 018 include:

Ford (2017) Characterization of structurally novel G protein biased CB1 agonists: implications for drug development. Pharmacol Res. 125:161
PMID: 28838808

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Product Documents for JWH 018

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.