IPSU

Name: IPSU
Brand: Tocris Bioscience
SKU: 5645

Tocris Bioscience, part of Bio-Techne | Catalog # 5645

COA / SDS

OX2 antagonist; orally bioavailable

Discontinued Product

5645 has been discontinued. View all Orexin Receptor Antagonists products.

Key Product Details

Description:	OX₂ antagonist; orally bioavailable
Chemical Name:	2-(1H-Indol-3-ylmethyl)-9-(4-methoxy-2-pyrimidinyl)-2,9-diazaspiro[5.5]undecan-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	405.49

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Technical Data
Citations

Biological Activity for IPSU

OX₂ receptor antagonist. Exhibits approximately six-fold selectivity for OX₂ versus OX₁ receptors. Decreases activity and increases sleep time in mice during the active phase, without affecting REM/NREM balance. Orally bioavailable. Brain penetrant.

Technical Data for IPSU

M. Wt	405.49
Formula	C₂₃H₂₇N₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1373765-19-5
PubChem ID	56970858
InChi Key	PCMHOSYCWRRHTG-UHFFFAOYSA-N
Smiles	COC1=CC=NC(N2CCC3(C(N(CC4=CNC5=C4C=CC=C5)CCC3)=O)CC2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for IPSU

References are publications that support the biological activity of the product.

Betschart Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J.Med.Chem. 2013 PMID: 23964859
Hoyer Distinct effects of IPSU and suvorexant on mouse sleep architecture. Front.Neurosci. 2013 PMID: 24376396

IPSU

Tocris Bioscience, part of Bio-Techne | Catalog # 5645

Key Product Details

Biological Activity for IPSU

Technical Data for IPSU

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for IPSU

Product Documents for IPSU

COA

Certificate of Analysis

SDS

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