INCA-6

Name: INCA-6
Brand: Tocris Bioscience
SKU: 2162

Catalog # 2162 | Tocris Bioscience a Bio-Techne Brand

Citations (3)

COA / SDS

Inhibitor of calcineurin-substrate association

Key Product Details

Description:	Inhibitor of calcineurin-substrate association
Chemical Name:	9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
Purity:	≥95% (HPLC)
Molecular Weight:	284.31

View Full Technical Details for INCA-6

Technical Data
Citations (3) / Reviews

Biological Activity for INCA-6

INCA-6 is an inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (K_d = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

Technical Data for INCA-6

M. Wt	284.31
Formula	C₂₀H₁₂O₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	3519-82-2
PubChem ID	230748
InChi Key	GCHPUOHXXCNSQL-UHFFFAOYSA-N
Smiles	O=C1C=CC(=O)C2=C1C1C3=C(C=CC=C3)C2C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for INCA-6

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.69	20

Preparing Stock Solutions for INCA-6

The following data is based on the product molecular weight 284.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	17.59 mL	87.93 mL	175.86 mL
1 mM	3.52 mL	17.59 mL	35.17 mL
2 mM	1.76 mL	8.79 mL	17.59 mL
10 mM	0.35 mL	1.76 mL	3.52 mL

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References for INCA-6

References are publications that support the biological activity of the product.

Roehrl Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci.USA

Citations for INCA-6 (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for INCA-6 include:

Savage et al. (2015) RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα. PLoS One. 10:e0116941
PMID: 25617622
Bretz et al. (2015) NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis. Exp Eye Res. 5:14963
PMID: 26527057
Faralli et al. (2015) NFATc1 activity regulates the expression of myocilin induced by dexameth. Nat Chem Biol. 130:42614
PMID: 25450062

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