HODHBt

Name: HODHBt
Brand: Tocris Bioscience
SKU: 6994

Tocris Bioscience, part of Bio-Techne | Catalog # 6994

Citations (3)

COA / SDS

STAT5-SUMO protein-protein interaction inhibitor

Discontinued Product

6994 has been discontinued. View all Antiviral Compounds products.

Key Product Details

Description:	STAT5-SUMO protein-protein interaction inhibitor
Chemical Name:	3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	163.14

View Full Technical Details for HODHBt

Technical Data
Citations

Biological Activity for HODHBt

HODHBt is a STAT5-SUMO protein-protein interaction inhibitor. Blocks SUMOylation of phosphorylated STAT5. Reactivates latent HIV-1 reservoir in central memory T cells (T_CM). Increases viral release by ~2.7-fold at a concentration of 100 μM in combination with IL-2 compared to unstimulated cells; reduces size of latent HIV-1 reservoir in vitro.

Technical Data for HODHBt

M. Wt	163.14
Formula	C₇H₅N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	28230-32-2
PubChem ID	73026
InChi Key	HJBLUNHMOKFZQX-UHFFFAOYSA-N
Smiles	ON1N=NC2=CC=CC=C2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for HODHBt

References are publications that support the biological activity of the product.

Bosque Benzotriazoles reactivate latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Rep. 2017 PMID: 28147284

HODHBt

Tocris Bioscience, part of Bio-Techne | Catalog # 6994

Key Product Details

Biological Activity for HODHBt

Technical Data for HODHBt

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for HODHBt

Product Documents for HODHBt

COA

Certificate of Analysis

SDS

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