Hexa-D-arginine

Name: Hexa- D -arginine
Brand: Tocris Bioscience
SKU: 4711

Tocris Bioscience, part of Bio-Techne | Catalog # 4711

Citations (7)

COA / SDS

Furin inhibitor

Discontinued Product

4711 has been discontinued. View all Furin Inhibitors products.

Key Product Details

Description:	Furin inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	954.16

View Full Technical Details for Hexa-D-arginine

Technical Data
Citations

Biological Activity for Hexa-D-arginine

Hexa-D-arginine is an inhibitor of furin (K_i values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).

Technical Data for Hexa-D-arginine

M. Wt	954.16
Formula	C₃₆H₇₅N₂₅O₆
Single Letter Sequence	RRRRRR (Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6 = D-Arg)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	673202-67-0
PubChem ID	57358476
InChi Key	BMLTZEAFQLJTIZ-TZNXUKFXSA-N
Smiles	[H]N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Hexa-D-arginine

References are publications that support the biological activity of the product.

Cameron Polyarginines are potent furin inhibitors. J.Biol.Chem. 2000 PMID: 10958789
Cheng Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 2020 PMID: 33007239
Yuan Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. J.Bone Miner.Res. 2012 PMID: 22886699

Hexa-D-arginine

Tocris Bioscience, part of Bio-Techne | Catalog # 4711

Key Product Details

Biological Activity for Hexa-D-arginine

Technical Data for Hexa-D-arginine

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Hexa-D-arginine

Product Documents for Hexa-D-arginine

COA

Certificate of Analysis

SDS

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