H-7 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 0542

Protein kinase inhibitor
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Key Product Details

Description

Protein kinase inhibitor

View all Broad Spectrum Protein Kinase Inhibitors »

Product Description

H-7 dihydrochloride is a protein kinase inhibitor (IC50 values for inhibition of PKA, PKG, PKC and myosin light chain kinase are 3.0, 5.8, 6.0 and 97.0 μM, respectively. H-7 shows antiviral activity against influenza A (IC50 = 10 μM) in vitro. H-7 also inhibits interleukin-stimulated secretion of IgM and blocks PMA-stimulated interleukin 1β production.

Product Specifications

Molecular Weight

364.29

Formula

C14H17N3O2S.2HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride

CAS Number

108930-17-2

PubChem ID

73332

InChI Key

OARGPFMFRLLKPF-UHFFFAOYSA-N

SMILES

Cl.Cl.CC1CNCCN1S(=O)(=O)C1=CC=CC2=CN=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.43 100
DMSO 7.29 20

Preparing Stock Solutions for H-7 dihydrochloride

The following data is based on the product molecular weight 364.29

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.73 mL 27.45 mL
5 mM 0.55 mL 2.75 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Calculators

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Product Documents for H-7 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for H-7 dihydrochloride

For research use only

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