Golgicide A

Name: Golgicide A
Brand: Tocris Bioscience
SKU: 3584

Tocris Bioscience a Bio-Techne Brand

Catalog # 3584

Citations (2)

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Key Product Details

Description:	Potent, selective and reversible inhibitor of GBF1 ArfGEF
Chemical Name:	6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Purity:	≥98% (HPLC)
Molecular Weight:	284.3

View Full Technical Details for Golgicide A

Biological Activity for Golgicide A

Golgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.

Technical Data for Golgicide A

M. Wt	284.3
Formula	C₁₇H₁₄F₂N₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1139889-93-2
PubChem ID	25113626
InChi Key	NJZHEQOUHLZCOX-FTLRAWMYSA-N
Smiles	FC4=CC([C@]3([H])[C@]([H])2CC=C3)=C(C(F)=C4)NC2C1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Golgicide A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	14.21	50

Preparing Stock Solutions for Golgicide A

The following data is based on the product molecular weight 284.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.03 mL	35.17 mL	70.35 mL
2.5 mM	1.41 mL	7.03 mL	14.07 mL
5 mM	0.70 mL	3.52 mL	7.03 mL
25 mM	0.14 mL	0.70 mL	1.41 mL

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References for Golgicide A

References are publications that support the biological activity of the product.

Saenz Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem.Biol.

Citations for Golgicide A (2)

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Citations are publications that use Bio-Techne products. Selected citations for Golgicide A include:

Gomes-da-Silva et al. (2019) Recruitment of LC3 to damaged Golgi apparatus. Cell Death Differ. 26:1467
PMID: 30349077
Krokowski (2017) GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells. Cell Rep. 21(10):2895
PMID: 29212034

There are no citations that match your criteria.