Gabapentin

Name: Gabapentin
Brand: tocris
SKU: 0806

Catalog # 0806

Citations (1)

Datasheet / COA / SDS

Discontinued Product

0806 has been discontinued. View all Additional GABA Compounds products.

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Bio-Techne Corporation

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$35 to United States

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Key Product Details

Description:	Increases brain GABA; anticonvulsant
Chemical Name:	1-(Aminomethyl)cyclohexaneacetic acid
Purity:	≥99%
Molecular Weight:	171.24

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Biological Activity

Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca²⁺ channels. Prevents neuronal death and is antinociceptive and anxiolytic.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt	171.24
Formula	C₉H₁₇NO₂
Storage	Desiccate at +4°C
Purity	≥99%
CAS Number	60142-96-3
PubChem ID	3446
InChi Key	UGJMXCAKCUNAIE-UHFFFAOYSA-N
Smiles	NCC1(CC(O)=O)CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	17.12	100 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 171.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.84 mL	29.20 mL	58.40 mL
5 mM	1.17 mL	5.84 mL	11.68 mL
10 mM	0.58 mL	2.92 mL	5.84 mL
50 mM	0.12 mL	0.58 mL	1.17 mL

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References

References are publications that support the biological activity of the product.

Fink Inhibition of Ca²⁺ influx by gabap. and subsequent reduction of neurotransmitter release from rat neocortical slices. Br.J.Pharmacol. 2000 PMID: 10864898
Taylor A summary of mechanistic hypotheses of gabap. pharmacology. Epilepsy Res. 1998 PMID: 9551785
Timmerman A microdialysis study on the mechanism of action of gabap. Eur.J.Pharmacol. 2000 PMID: 10856447
Upton Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 1994 PMID: 7886818

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Gabapentin include:

Sant'Anna et al. (2016) Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. J Neurosci. 6:26955
PMID: 27230787

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Gabapentin

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References

Citations (1)

Product Datasheets

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