FGIN-1-27

Name: FGIN-1-27
Brand: Tocris Bioscience
SKU: 0658

Tocris Bioscience, part of Bio-Techne | Catalog # 0658

Citations (11)

COA / SDS

Potent, specific ligand for mitochondrial DBI receptor

Discontinued Product

0658 has been discontinued. View all Other Translocator Protein Compounds products.

Key Product Details

Description:	Potent, specific ligand for mitochondrial DBI receptor
Chemical Name:	N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	436.61

View Full Technical Details for FGIN-1-27

Technical Data
Citations

Biological Activity for FGIN-1-27

Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC₅₀ = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.

Technical Data for FGIN-1-27

M. Wt	436.61
Formula	C₂₈H₃₇FN₂O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	142720-24-9
PubChem ID	132496
InChi Key	VUWXAQFLTSBUDB-UHFFFAOYSA-N
Smiles	O=C(N(CCCCCC)CCCCCC)CC2=C(C3=CC=C(F)C=C3)NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for FGIN-1-27

References are publications that support the biological activity of the product.

Kozikowski Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABA_A receptor modulation. Angew.Chem.Int.Ed.
Romeo 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J.Pharmacol.Exp.Ther. 1992 PMID: 1326631

FGIN-1-27

Tocris Bioscience, part of Bio-Techne | Catalog # 0658

Key Product Details

Biological Activity for FGIN-1-27

Technical Data for FGIN-1-27

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for FGIN-1-27

Product Documents for FGIN-1-27

COA

Certificate of Analysis

SDS

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