FGIN-1-27

Name: FGIN-1-27
Brand: Tocris Bioscience
SKU: 0658

Tocris Bioscience a Bio-Techne Brand

Catalog # 0658

Citations (1)

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Key Product Details

Description:	Potent, specific ligand for mitochondrial DBI receptor
Chemical Name:	N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	436.61

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Biological Activity for FGIN-1-27

Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC₅₀ = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.

Technical Data for FGIN-1-27

M. Wt	436.61
Formula	C₂₈H₃₇FN₂O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	142720-24-9
PubChem ID	132496
InChi Key	VUWXAQFLTSBUDB-UHFFFAOYSA-N
Smiles	O=C(N(CCCCCC)CCCCCC)CC2=C(C3=CC=C(F)C=C3)NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FGIN-1-27

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.66	100

Preparing Stock Solutions for FGIN-1-27

The following data is based on the product molecular weight 436.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.45 mL	22.90 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.15 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for FGIN-1-27

References are publications that support the biological activity of the product.

Romeo 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J.Pharmacol.Exp.Ther. 1992 PMID: 1326631
Kozikowski Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABA_A receptor modulation. Angew.Chem.Int.Ed.

Citations for FGIN-1-27 (1)

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Citations are publications that use Bio-Techne products. Selected citations for FGIN-1-27 include:

Sutter et al. (2003) Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Glia. 89:564
PMID: 12888831

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