Epirubicin hydrochloride

Name: Epirubicin hydrochloride
Brand: Tocris Bioscience
SKU: 3260
Rating: 5 (2 reviews)

Catalog # 3260 | Tocris Bioscience a Bio-Techne Brand

(2)

Citations (2)

COA / SDS

Inhibits DNA synthesis and function. Inhibits DNA topoisomerase II

Key Product Details

Description:	Inhibits DNA synthesis and function. Inhibits DNA topoisomerase II
Alternative Names:	4'-Epidoxorubicin
Chemical Name:	(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride
Purity:	≥96% (HPLC)
Molecular Weight:	579.98

View Full Technical Details for Epirubicin hydrochloride

Biological Activity for Epirubicin hydrochloride

Epirubicin hydrochloride is an antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC₅₀ = 62.7 μM in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.

Technical Data for Epirubicin hydrochloride

M. Wt	579.98
Formula	C₂₇H₂₉NO₁₁.HCl
Storage	Desiccate at +4°C
Purity	≥96% (HPLC)
CAS Number	56390-09-1
PubChem ID	32874
InChi Key	MWWSFMDVAYGXBV-FGBJBKNOSA-N
Smiles	O=C(C2=C1C(OC)=CC=C2)C3=C(C(O)=C([C@](OC5CC(N)C(O)C(C)O5)([H])C[C@@]([C@@](CO)=O)(O)C4)C4=C3O)C1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Epirubicin hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	58	100
	water	29	50

Preparing Stock Solutions for Epirubicin hydrochloride

The following data is based on the product molecular weight 579.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.72 mL	8.62 mL	17.24 mL
5 mM	0.34 mL	1.72 mL	3.45 mL
10 mM	0.17 mL	0.86 mL	1.72 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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References for Epirubicin hydrochloride

References are publications that support the biological activity of the product.

Schott and Robert Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture. Biochem.Pharmacol. 1989 PMID: 2597184
Cersosimo Epirubicin: a review of pharmacology, clinical activity, and adverse effects of an adriamycin analogue. J.Clin.Oncol. 1986 PMID: 3005521
Spadari DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs. Anticancer Res. 1986 PMID: 3026237

Citations for Epirubicin hydrochloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for Epirubicin hydrochloride include:

Kim and Bynoe (2016) A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest. 126:1717
PMID: 27043281
Robinson et al. (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One. 8:e78641
PMID: 24265703

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Customer Reviews for Epirubicin hydrochloride (2)

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Highly stable

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

Cell Line/Tissue: brain

10 mg/kg of epirubicin

PMID: 27043281
Epirubicin effectively kills melanoma cells in vitro

Name: Anonymous

Species: Human

Assay Type: In Vitro

Epirubicin was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

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Product Documents for Epirubicin hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.