Eliprodil

Name: Eliprodil
Brand: Tocris Bioscience
SKU: 2195
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 2195

Citations (2)

(1)

COA / SDS

Discontinued Product

2195 has been discontinued. View all NMDA Receptor Antagonists products.

Key Product Details

Description:	Non-competitive and GluN2B-selective NMDA antagonist
Chemical Name:	α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
Purity:	≥98% (HPLC)
Molecular Weight:	347.86

View Full Technical Details for Eliprodil

Biological Activity for Eliprodil

Eliprodil is a non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for GluN2B (formally NR2B)- over GluN2A (NR2A)- and GluN2C (NR2C)-containing receptors (IC₅₀ values are 1, > 100 and > 100 μM respectively). Also σ₁ ligand (K_i = 0.013 μM). Antagonizes neuronal voltage-gated Ca²⁺ channels and selectively inhibits the rapid component of the delayed rectifier K⁺ current (I_Kr). Neuroprotective.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Compound Libraries for Eliprodil

Eliprodil is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Eliprodil

M. Wt	347.86
Formula	C₂₀H₂₃ClFNO
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	119431-25-3
PubChem ID	60703
InChi Key	GGUSQTSTQSHJAH-UHFFFAOYSA-N
Smiles	OC(CN1CCC(CC2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Eliprodil

References are publications that support the biological activity of the product.

Lengyel Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br.J.Pharmacol. 2004 PMID: 15302678
Whittemore Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 1997 PMID: 9223571
Bath The effects of ifenprodil and eliprodil on voltage-dependent Ca²⁺ channels and in gerbil global cerebral ischaemia. Eur.J.Pharmacol. 1996 PMID: 8901012

Citations for Eliprodil (2)

Showing 1 - 2 of 2 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Eliprodil include:

Rennekamp et al. (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 12:552
PMID: 27239788
Hedegaard et al. (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int. 61:601
PMID: 22197913

There are no citations that match your criteria.

Showing 1 - 2 of 2 citations Showing All

Customer Reviews for Eliprodil (1)

5 out of 5

1 customer rating

5 stars

100%

4 stars

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

Evaluate the efficacity and the window of therapeutic opportunity of Eliprodil

Name: Anonymous

Species: Human

We studied the histological assessment of the volume of the traumatic brain lesion to estimate the extent of the structural damage. In the study, we have used this approach to evaluate the efficacity and the window of therapeutic opportunity of Eliprodil.

There are no reviews that match your criteria.

Showing 1 - 1 of 1 review Showing All

Product Documents for Eliprodil

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.