d[Leu⁴,Lys⁸]-VP

Name: d[Leu 4 ,Lys 8 ]-VP
Brand: Tocris Bioscience
SKU: 3127

Tocris Bioscience, part of Bio-Techne | Catalog # 3127

Citations (17)

COA / SDS

Selective V1B agonist

Discontinued Product

3127 has been discontinued. View all Vasopressin Receptor Agonists products.

Key Product Details

Description:	Selective V_1B agonist
Molecular Weight:	1026.2

View Full Technical Details for d[Leu⁴,Lys⁸]-VP

Technical Data
Citations

Biological Activity for d[Leu⁴,Lys⁸]-VP

d[Leu⁴,Lys⁸]-VP is a selective vasopressin V_1B receptor agonist (K_i values are 0.16, 64, 100 and 3800 nM for V_1B, oxytocin, V₂ and V_1A receptors respectively). Displays weak antidiuretic, vasopressor and in vitro oxytocic activities.

Technical Data for d[Leu⁴,Lys⁸]-VP

M. Wt	1026.2
Formula	C₄₇H₆₇N₁₁O₁₁S₂
Single Letter Sequence	XYFLNCPKG (Modifications: X = Mpr, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6)
Storage	Store at -20°C
CAS Number	42061-33-6
PubChem ID	44419030
InChi Key	QGZMLGLFLYCDQT-PEAOEFARSA-N
Smiles	CC(C)C[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for d[Leu⁴,Lys⁸]-VP

References are publications that support the biological activity of the product.

Pena Pharmacological and physiological characterization of d[Leu⁴,Lys⁸]vasopressin, the first V_1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology 2007 PMID: 17495006
Pena Design and synthesis of the frist selective agonists for the rat vasopressin V_1b receptor: based on modifications of deamino-[cys¹]arginine vasopressin at positions 4 and 8. J.Med.Chem. 2007 PMID: 17300166

d[Leu⁴,Lys⁸]-VP

Tocris Bioscience, part of Bio-Techne | Catalog # 3127

Key Product Details

Biological Activity for d[Leu⁴,Lys⁸]-VP

Technical Data for d[Leu⁴,Lys⁸]-VP

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for d[Leu⁴,Lys⁸]-VP

Product Documents for d[Leu⁴,Lys⁸]-VP

COA

Certificate of Analysis

SDS

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d[Leu4,Lys8]-VP

Tocris Bioscience, part of Bio-Techne | Catalog # 3127

Key Product Details

Biological Activity for d[Leu4,Lys8]-VP

Technical Data for d[Leu4,Lys8]-VP

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for d[Leu4,Lys8]-VP

Product Documents for d[Leu4,Lys8]-VP

COA

Certificate of Analysis

SDS

d[Leu⁴,Lys⁸]-VP

Biological Activity for d[Leu⁴,Lys⁸]-VP

Technical Data for d[Leu⁴,Lys⁸]-VP

References for d[Leu⁴,Lys⁸]-VP

Product Documents for d[Leu⁴,Lys⁸]-VP