(±)-Vesamicol hydrochloride

Name: (±)-Vesamicol hydrochloride
Brand: tocris
SKU: 0653

Catalog # 0653

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

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Key Product Details

Description:	Inhibits ACh transport
Alternative Names:	AH 5183
Chemical Name:	(±)-trans-2-(4-Phenylpiperidinyl)cyclohexanol hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	295.85

View Full Technical Details for (±)-Vesamicol hydrochloride

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Biological Activity

Inhibitor of acetylcholine transport (K_i = 2 nM). Centrally active following systemic administration in vivo.

Compound Libraries

(±)-Vesamicol hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	295.85
Formula	C₁₇H₂₅NO.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	120447-62-3
PubChem ID	659839
InChi Key	XJNUHVMJVWOYCW-GBNZRNLASA-N
Smiles	O[C@@H]1CCCC[C@H]1N(CC3)CCC3C2=CC=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	5.92	20
	DMSO	14.79	50 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 295.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.76 mL	33.80 mL	67.60 mL
2.5 mM	1.35 mL	6.76 mL	13.52 mL
5 mM	0.68 mL	3.38 mL	6.76 mL
25 mM	0.14 mL	0.68 mL	1.35 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Efange N-hydroxyalkyl derivatives of 3β-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J.Med.Chem. 1997 PMID: 9397171
Kobayashi Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res.Bull. 1997 PMID: 9205789
Varoqui and Erickson Active transport of acetylcholine by the human vesicular acetylcholine transporter. J.Biol.Chem. 1996 PMID: 8910293