Dimebon dihydrochloride

Name: Dimebon dihydrochloride
Brand: Tocris Bioscience
SKU: 3201

Tocris Bioscience a Bio-Techne Brand

Catalog # 3201

COA / SDS

Discontinued Product

3201 has been discontinued. View all Amyloid beta Peptides products.

Key Product Details

Description:	Neuroprotectant; protects against β-amyloid neurotoxicity
Alternative Names:	Dimebone, Latrepirdine
Chemical Name:	2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride
Purity:	≥98%
Molecular Weight:	392.37

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Biological Activity for Dimebon dihydrochloride

Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT₆ and 5-HT₇), α-adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Does not inhibit acetylcholinesterase activity. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β-amyloid fragment; shown to enhance autophagy in yeast and reduce intracellular Aβ42 levels.

Technical Data for Dimebon dihydrochloride

M. Wt	392.37
Formula	C₂₁H₂₅N₃.2HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	97657-92-6
PubChem ID	23729232
InChi Key	GTWLIQOLGOZTLF-UHFFFAOYSA-N
Smiles	CC(N=C4)=CC=C4CCN2C1=CC=C(C)C=C1C3=C2CCN(C)C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dimebon dihydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for Dimebon dihydrochloride

References are publications that support the biological activity of the product.

Bharadwaj Latrepirdine (Dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. J.Alzheimers Dis. 2012 PMID: 22903131
Giorgetti Cognition-enhancing properties of dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-MthD.-aspartate receptor antagonism J.Pharm.Exp.Ther.
Schaffhauser Dimebon is a 5-HT₆ antagonist with acute cognitive enhancing activities. Biochem.Pharmacol. 2009 PMID: 19549510
Okun From anti-allergic to anti-Alzheimer's: molecular pharmacology of dimebon. Curr.Alzheimer Res.
Bachurin Antihistamine agent dimebon as a novel neuroprotector and a cognitive enhancer. Ann.N.Y.Acad.Sci. 2001 PMID: 11462798

Citations for Dimebon dihydrochloride

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Dimebon dihydrochloride

Tocris Bioscience a Bio-Techne Brand

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Biological Activity for Dimebon dihydrochloride

Technical Data for Dimebon dihydrochloride

Solubility for Dimebon dihydrochloride

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Dilution Calculator

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References for Dimebon dihydrochloride

Citations for Dimebon dihydrochloride

Product Documents for Dimebon dihydrochloride

COA

Certificate of Analysis

SDS

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