DFB

Name: DFB
Brand: Tocris Bioscience
SKU: 1625

Tocris Bioscience, part of Bio-Techne | Catalog # 1625

Citations (6)

COA / SDS

Positive allosteric modulator of mGlu5 receptors

Discontinued Product

1625 has been discontinued. View all Group I mGluR Modulators products.

Key Product Details

Description:	Positive allosteric modulator of mGlu₅ receptors
Alternative Names:	3,3'-Difluorobenzaldazine
Chemical Name:	[(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde
Purity:	≥99% (HPLC)
Molecular Weight:	244.24

View Full Technical Details for DFB

Technical Data
Citations

Biological Activity for DFB

DFB is a novel allosteric potentiator of the metabotropic glutamate receptor mGlu₅. Devoid of agonist activity itself, but potentiates (3 - 6-fold) the action of agonists at mGlu₅ without any effect at other mGlu subtypes (EC₅₀ for potentiation = 2 - 5.3 μM).

Technical Data for DFB

M. Wt	244.24
Formula	C₁₄H₁₀F₂N₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	15332-10-2
PubChem ID	52942441
InChi Key	DYNGCIHMNWOBSU-MSQVLRTGSA-K
Smiles	FC1=CC(=CC=C1)\C=N\N=C\C1=CC=CC(F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for DFB

References are publications that support the biological activity of the product.

Zhang Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. J.Pharmacol.Exp.Ther. 2005 PMID: 16135701
Williams DFB, an allosteric potentiator of mGluR5 4th International Meeting on Metabotropic Glutamat
O'Brien A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol.Pharmacol. 2003 PMID: 12920211

DFB

Tocris Bioscience, part of Bio-Techne | Catalog # 1625

Key Product Details

Biological Activity for DFB

Technical Data for DFB

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for DFB

Product Documents for DFB

COA

Certificate of Analysis

SDS

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