D-64131

Name: D-64131
Brand: Tocris Bioscience
SKU: 1643
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1643

(1)

COA / SDS

Tubulin polymerization inhibitor. Antitumor in vivo

Discontinued Product

1643 has been discontinued. View all Microtubule Binding Compounds products.

Key Product Details

Description:	Tubulin polymerization inhibitor. Antitumor in vivo
Chemical Name:	(5-Methoxy-1H-indol-2-yl)phenylmethanone
Purity:	≥99% (HPLC)
Molecular Weight:	251.28

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Technical Data
Citations / Reviews (1)

Biological Activity for D-64131

D-64131 is a novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC₅₀ = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.

Technical Data for D-64131

M. Wt	251.28
Formula	C₁₆H₁₃NO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	74588-78-6
PubChem ID	3921152
InChi Key	ICMIJSRDISNKOC-UHFFFAOYSA-N
Smiles	COC1=CC=C2NC(=CC2=C1)C(=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for D-64131

References are publications that support the biological activity of the product.

Mahboobi Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J.Med.Chem. 2001 PMID: 11741473
Beckers 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 2002 PMID: 12036922

D-64131

Tocris Bioscience, part of Bio-Techne | Catalog # 1643

Key Product Details

Biological Activity for D-64131

Technical Data for D-64131

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for D-64131

Product Documents for D-64131

COA

Certificate of Analysis

SDS

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