Cyclapolin 9

Name: Cyclapolin 9
Brand: Tocris Bioscience
SKU: 3116

Tocris Bioscience a Bio-Techne Brand

Catalog # 3116

Citations (1)

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Key Product Details

Description:	Selective, ATP-competitive PLK1 inhibitor
Chemical Name:	7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide
Purity:	≥98% (HPLC)
Molecular Weight:	307.21

View Full Technical Details for Cyclapolin 9

Biological Activity for Cyclapolin 9

Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC₅₀ = 500 nM).

Technical Data for Cyclapolin 9

M. Wt	307.21
Formula	C₉H₄F₃N₃O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	40533-25-3
PubChem ID	2779952
InChi Key	FHFLXKUKCSDMLD-UHFFFAOYSA-N
Smiles	[O-][N+]2=C(C(N)=O)SC1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyclapolin 9

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	7.68	25
	ethanol	3.07	10

Preparing Stock Solutions for Cyclapolin 9

The following data is based on the product molecular weight 307.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	13.02 mL	65.10 mL	130.20 mL
1.25 mM	2.60 mL	13.02 mL	26.04 mL
2.5 mM	1.30 mL	6.51 mL	13.02 mL
12.5 mM	0.26 mL	1.30 mL	2.60 mL

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References for Cyclapolin 9

References are publications that support the biological activity of the product.

Taylor Ligand discovery and virtual screening using the program LIDAEUS. Br.J.Pharmacol. 2008 PMID: 18037921
McInnes Inhibitors of polo-like kinase reveal roles in spindle pole maintenance. Nature Chem.Biol.

Citations for Cyclapolin 9 (1)

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Citations are publications that use Bio-Techne products. Selected citations for Cyclapolin 9 include:

Cozzoli et al. (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Proc Natl Acad Sci U S A. 36:1623
PMID: 22432643

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