(-)-Cotinine

Name: (-)-Cotinine
Brand: Tocris Bioscience
SKU: 3110

Tocris Bioscience, part of Bio-Techne | Catalog # 3110

COA / SDS

Major metabolite of nicotine

Discontinued Product

3110 has been discontinued. View all Additional Nicotinic Receptor Agonists products.

Key Product Details

Description:	Major metabolite of nicotine
Chemical Name:	(S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
Purity:	≥99% (HPLC)
Molecular Weight:	176.22

View Full Technical Details for (-)-Cotinine

Technical Data
Citations

Biological Activity for (-)-Cotinine

Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.

Technical Data for (-)-Cotinine

M. Wt	176.22
Formula	C₁₀H₁₂N₂O
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	486-56-6
PubChem ID	854019
InChi Key	UIKROCXWUNQSPJ-VIFPVBQESA-N
Smiles	CN(C(CC2)=O)[C@@H]2[C@]1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for (-)-Cotinine

References are publications that support the biological activity of the product.

Terry Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev. 2005 PMID: 16389292
Echeverria Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. J.Alzheimers Dis. 2011 PMID: 20930295
Buccafusco and Terry The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life Sci. 2003 PMID: 12706481

(-)-Cotinine

Tocris Bioscience, part of Bio-Techne | Catalog # 3110

Key Product Details

Biological Activity for (-)-Cotinine

Technical Data for (-)-Cotinine

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for (-)-Cotinine

Product Documents for (-)-Cotinine

COA

Certificate of Analysis

SDS

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