CMPD-1

Name: CMPD-1
Brand: Tocris Bioscience
SKU: 2186
Rating: 4 (1 reviews)

Catalog # 2186 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (3)

COA / SDS

Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor

Key Product Details

Description:	Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor
Chemical Name:	2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide
Purity:	≥99% (HPLC)
Molecular Weight:	349.4

View Full Technical Details for CMPD-1

Technical Data
Citations (3) / Reviews (1)

Biological Activity for CMPD-1

CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent K_i = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.

Compound Libraries for CMPD-1

CMPD-1 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for CMPD-1

M. Wt	349.4
Formula	C₂₂H₂₀FNO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	41179-33-3
PubChem ID	11382492
InChi Key	ODYAQBDIXCVKAE-UHFFFAOYSA-N
Smiles	OC1=CC=C(NC(=O)CCCC2=CC=C(C=C2)C2=CC=CC=C2F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CMPD-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.94	100
	ethanol	34.94	100

Preparing Stock Solutions for CMPD-1

The following data is based on the product molecular weight 349.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL
10 mM	0.29 mL	1.43 mL	2.86 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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Reconstitution Calculator

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References for CMPD-1

References are publications that support the biological activity of the product.

Gurgis Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discovery
Davidson Discovery and characterisation of a substrate selective p38α inhibitor. Biochemistry 2004 PMID: 15362850

Citations for CMPD-1 (3)

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Citations are publications that use Bio-Techne products. Selected citations for CMPD-1 include:

Ryals et al. (2018) The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci. 12:445
PMID: 30532693
Breindel et al. (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res. 73:5053
PMID: 23794705
Fricke et al. (2013) p38 and OGT sequestration into viral inclusion bodies in cells infected with human respiratory syncytial virus suppresses MK2 activities and stress granule assembly. J Virol. 87:1333
PMID: 23152511

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Customer Reviews for CMPD-1 (1)

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42 perturbagens used the zebrafish DASPEI screen

Name: Anonymous

Species: Other

Assay Type: In Vivo

Cell Line/Tissue: larvae

Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound

PMID: 30532693

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