Clomipramine hydrochloride

Name: Clomipramine hydrochloride
Brand: tocris
SKU: 0457

Catalog # 0457

Citations (3)

Datasheet / COA / SDS

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Key Product Details

Description:	5-HT reuptake inhibitor
Chemical Name:	3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	351.32

View Full Technical Details for Clomipramine hydrochloride

Biological Activity

Clomipramine hydrochloride is a potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a K_i of 0.05 nmol/l.

Technical Data

M. Wt	351.32
Formula	C₁₉H₂₃ClN₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	17321-77-6
PubChem ID	68539
InChi Key	WIMWMKZEIBHDTH-UHFFFAOYSA-N
Smiles	Cl.CN(C)CCCN1C2=CC(Cl)=CC=C2CCC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	35.13	100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.23 mL	28.46 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References

References are publications that support the biological activity of the product.

McTavish and Benfield Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 1990 PMID: 2178909
Ortiz and Artiga Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluox. Br.J.Pharmacol. 1992 PMID: 1387022
Owens Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 1997 PMID: 9400006
Merck Index

Citations (3)

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Citations are publications that use Bio-Techne products. Selected citations for Clomipramine hydrochloride include:

Conley et al. (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. Eur J Neurosci. 352:53
PMID: 25332454
Stuart et al. (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology. 38:1625
PMID: 23503126
Duncan et al. (2010) The effects of aging and chronic fluox. treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors. J Biomed Sci. 31:1646
PMID: 20525077

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Clomipramine hydrochloride

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References

Citations (3)

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