CCT 137690

Name: CCT 137690
Brand: Tocris Bioscience
SKU: 4291

Tocris Bioscience a Bio-Techne Brand

Catalog # 4291

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Key Product Details

Description:	Potent pan-Aurora kinase inhibitor
Chemical Name:	6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine
Purity:	≥98% (HPLC)
Molecular Weight:	551.48

View Full Technical Details for CCT 137690

Biological Activity for CCT 137690

CCT 137690 is a potent inhibitor of Aurora kinases (IC₅₀ values are 0.015, 0.019 and 0.025 μM at Aurora A, Aurora C and Aurora B respectively). Displays antiproliferative activity in a range of human tumor cell lines. Orally bioavailable.

Technical Data for CCT 137690

M. Wt	551.48
Formula	C₂₆H₃₁BrN₈O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1095382-05-0
PubChem ID	25154041
InChi Key	GFLQCBTXTRCREJ-UHFFFAOYSA-N
Smiles	CN(CC4)CCN4C(C=C3)=CC=C3C2=NC1=C(N5CCN(CC6=NOC(C)=C6)CC5)C(Br)=CN=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CCT 137690

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	55.15	100

Preparing Stock Solutions for CCT 137690

The following data is based on the product molecular weight 551.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.07 mL	18.13 mL
5 mM	0.36 mL	1.81 mL	3.63 mL
10 mM	0.18 mL	0.91 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for CCT 137690

References are publications that support the biological activity of the product.

Faisal The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol.Cancer Ther. 2011 PMID: 21885865
Bavetsias Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J.Med.Chem. 2010 PMID: 20565112

Citations for CCT 137690

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