CCCP

Name: CCCP
Brand: Tocris Bioscience
SKU: 0452
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0452

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Citations (32)

COA / SDS

Oxidative phosphorylation uncoupler

Key Product Details

Description:	Oxidative phosphorylation uncoupler
Chemical Name:	Carbonyl cyanide 3-chlorophenylhydrazone
Purity:	≥98% (HPLC)
Molecular Weight:	204.62

View Full Technical Details for CCCP

Technical Data
Citations / Reviews (1)

Biological Activity for CCCP

CCCP is a protonophore. It disrupts mitochondria membrane potential by transporting protons across the mitochondrial inner membrane, which interferes with the proton gradient and ATP synthesis. CCCP is a widely used as an uncoupler of oxidative phosphorylation to induce mitochondrial depolarization.

Technical Data for CCCP

M. Wt	204.62
Formula	C₉H₅ClN₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	555-60-2
PubChem ID	2603
InChi Key	UGTJLJZQQFGTJD-UHFFFAOYSA-N
Smiles	ClC1=CC=CC(N/N=C(C#N)\C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CCCP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.46	100

Preparing Stock Solutions for CCCP

The following data is based on the product molecular weight 204.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.89 mL	24.44 mL	48.87 mL
5 mM	0.98 mL	4.89 mL	9.77 mL
10 mM	0.49 mL	2.44 mL	4.89 mL
50 mM	0.10 mL	0.49 mL	0.98 mL

Molarity Calculator

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Reconstitution Calculator

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References for CCCP

References are publications that support the biological activity of the product.

Heytler and Pritchard A new class of uncoupling agents - carbonyl cyanide phenylhydrazones. Biochem.Biophys.Res.Commun. 1962 PMID: 13907155