CBR 5884

Name: CBR 5884
Brand: Tocris Bioscience
SKU: 5836

Tocris Bioscience, part of Bio-Techne | Catalog # 5836

Citations (1)

COA / SDS

Phosphoglycerate dehydrogenase (PHGDH) inhibitor

Discontinued Product

5836 has been discontinued. View all Dehydrogenase Inhibitors products.

Key Product Details

Description:	Phosphoglycerate dehydrogenase (PHGDH) inhibitor
Chemical Name:	Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	336.39

View Full Technical Details for CBR 5884

Technical Data
Citations

Biological Activity for CBR 5884

CBR 5884 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC₅₀ = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

Technical Data for CBR 5884

M. Wt	336.39
Formula	C₁₄H₁₂N₂O₄S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	681159-27-3
PubChem ID	4674993
InChi Key	QBVIRPJBDIZKBC-UHFFFAOYSA-N
Smiles	CCOC(C1=C(C(SC#N)=C(S1)NC(C2=CC=CO2)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for CBR 5884

References are publications that support the biological activity of the product.

Mullarky Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc.Natl.Acad.Sci.U.S.A. 2016 PMID: 26831078

CBR 5884

Tocris Bioscience, part of Bio-Techne | Catalog # 5836

Key Product Details

Biological Activity for CBR 5884

Technical Data for CBR 5884

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for CBR 5884

Product Documents for CBR 5884

COA

Certificate of Analysis

SDS

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