C 21

Name: C 21
Brand: Tocris Bioscience
SKU: 5128

Tocris Bioscience a Bio-Techne Brand

Catalog # 5128

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Key Product Details

Description:	Selective PRMT1 inhibitor
Molecular Weight:	2166.94

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Biological Activity for C 21

C 21 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1.

Technical Data for C 21

M. Wt	2166.94
Formula	C₉₀H₁₆₁ClN₃₆O₂₄
Single Letter Sequence	SGXGKGGKGLGKGGAKRHRKV (Modifications: Ser-1 = N-terminal Ac, X = N5-(2-Chloro-1-iminoethyl)]-Orn)
Storage	Store at -20°C
CAS Number	1229236-78-5
PubChem ID	46911727
InChi Key	OANJWIVLLOAGEG-CQSMXCMYSA-N
Smiles	CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)CCl)NC(=O)CNC(=O)[C@H](CO)NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C 21

Solubility

Soluble to 2mg/ml in water

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References for C 21

References are publications that support the biological activity of the product.

Obianyo and Thompson Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). J.Biol.Chem. 2012 PMID: 22219200
Obianyo A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem 2010 PMID: 20480486

Citations for C 21

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C 21

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Biological Activity for C 21

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References for C 21

Citations for C 21

Product Documents for C 21

COA

Certificate of Analysis

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