C 21

Name: C 21
Brand: Tocris Bioscience
SKU: 5128

Tocris Bioscience, part of Bio-Techne | Catalog # 5128

COA / SDS

Selective PRMT1 inhibitor

Discontinued Product

5128 has been discontinued. View all Protein Arginine Methyltransferase Inhibitors products.

Key Product Details

Description:	Selective PRMT1 inhibitor
Molecular Weight:	2166.94

View Full Technical Details for C 21

Technical Data
Citations

Biological Activity for C 21

C 21 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1.

Technical Data for C 21

M. Wt	2166.94
Formula	C₉₀H₁₆₁ClN₃₆O₂₄
Single Letter Sequence	SGXGKGGKGLGKGGAKRHRKV (Modifications: Ser-1 = N-terminal Ac, X = N5-(2-Chloro-1-iminoethyl)]-Orn)
Storage	Store at -20°C
CAS Number	1229236-78-5
PubChem ID	46911727
InChi Key	OANJWIVLLOAGEG-CQSMXCMYSA-N
Smiles	CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)CCl)NC(=O)CNC(=O)[C@H](CO)NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for C 21

References are publications that support the biological activity of the product.

Obianyo and Thompson Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). J.Biol.Chem. 2012 PMID: 22219200
Obianyo A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem 2010 PMID: 20480486

C 21

Tocris Bioscience, part of Bio-Techne | Catalog # 5128

Key Product Details

Biological Activity for C 21

Technical Data for C 21

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for C 21

Product Documents for C 21

COA

Certificate of Analysis

SDS

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