BU 226 hydrochloride

Name: BU 226 hydrochloride
Brand: Tocris Bioscience
SKU: 1091

Catalog # 1091

Citations (1)

COA / SDS

Discontinued Product

1091 has been discontinued. View all Imidazoline 2 (I2) Receptor Ligands products.

Order Information

Bio-Techne Corporation

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Shipping Information

$35 to United States

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Key Product Details

Description:	Potent, highly selective I₂ ligand
Chemical Name:	2-(4,5-Dihydroimidazol-2-yl)isoquinoline hydrochloride
Molecular Weight:	233.7

View Full Technical Details for BU 226 hydrochloride

Biological Activity

BU 226 hydrochloride is a high affinity ligand for I₂ imidazoline sites (K_i = 2.7 nM) with very high selectivity (> 2000-fold) over α₂-adrenoceptors (K_i = 6700 nM).

Technical Data

M. Wt	233.7
Formula	C₁₂H₁₁N₃.HCl
Storage	Store at RT
CAS Number	1186195-56-1
PubChem ID	56972194
InChi Key	NIGHNKWLMSRCOZ-UHFFFAOYSA-N
Smiles	Cl.C1CN=C(N1)C1=CC2=CC=CC=C2C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 233.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.28 mL	21.39 mL	42.79 mL
5 mM	0.86 mL	4.28 mL	8.56 mL
10 mM	0.43 mL	2.14 mL	4.28 mL
50 mM	0.09 mL	0.43 mL	0.86 mL

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References

References are publications that support the biological activity of the product.

Hudson Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 1999 PMID: 10415900
Lione BU226: A selective ligand for rat brain imidazoline I₂ sites. Soc.Neurosci.Abstr.

Citations for BU 226 hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for BU 226 hydrochloride include:

Gründemann et al. (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol. 137:910
PMID: 12411423

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