Borrelidin

Name: Borrelidin
Brand: Tocris Bioscience
SKU: 4706

Tocris Bioscience, part of Bio-Techne | Catalog # 4706

COA / SDS

Antiangiogenic; inhibits threonyl-tRNA synthetase

Discontinued Product

4706 has been discontinued. View all Synthase/Synthetase Inhibitors products.

Key Product Details

Description:	Antiangiogenic; inhibits threonyl-tRNA synthetase
Chemical Name:	(1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	489.64

View Full Technical Details for Borrelidin

Technical Data
Citations

Biological Activity for Borrelidin

Borrelidin is an antibiotic and antiangiogenic. Selectively inhibits threonyl-tRNA synthetase (ThrRS). Exhibits antiangiogenic activity in a mouse model of tumor angiogenesis. Induces apoptosis in capillary tube-forming endothelial cells; disrupts capillary tubes and inhibits their formation (IC₅₀ = 0.8 nM in rat aorta). Induces the unfolded protein response (UPR) and apoptosis in oral cancer cells.

Technical Data for Borrelidin

M. Wt	489.64
Formula	C₂₈H₄₃NO₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	7184-60-3
PubChem ID	5357974
InChi Key	OJCKRNPLOZHAOU-SLNPHPKOSA-N
Smiles	O[C@@H](C1)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@@H](O)\C(C#N)=C/C=C/C[C@]([C@]2([H])CCC[C@H]2C(O)=O)([H])OC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Borrelidin

References are publications that support the biological activity of the product.

Sidhu Borrelidin induces the unfolded protein response in oral cancer cells and Chop-dependent apoptosis. ACS Med.Chem.Lett. 2015 PMID: 26617965
Kawamura Anti-angiogenesis effect of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. J.Antibiot.(Tokyo). 2003 PMID: 14563161
Woolard Borrelidin modulates the alterntive splicing of VEGF in favour of anti-antiogenic isoforms. Chem.Sci. 2011 PMID: 22822423
Wakabayashi Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. J.Antibiot.(Tokyo). 1997 PMID: 9315080

Borrelidin

Tocris Bioscience, part of Bio-Techne | Catalog # 4706

Key Product Details

Biological Activity for Borrelidin

Technical Data for Borrelidin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Borrelidin

Product Documents for Borrelidin

COA

Certificate of Analysis

SDS

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