BMY 7378 dihydrochloride

Name: BMY 7378 dihydrochloride
Brand: Tocris Bioscience
SKU: 1006

Tocris Bioscience, part of Bio-Techne | Catalog # 1006

Citations (30)

COA / SDS

Selective α1D antagonist

Discontinued Product

1006 has been discontinued. View all Adrenergic alpha-1 Receptor Antagonists products.

Key Product Details

Description:	Selective α_1D antagonist
Chemical Name:	8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
Molecular Weight:	458.42

View Full Technical Details for BMY 7378 dihydrochloride

Technical Data
Citations

Biological Activity for BMY 7378 dihydrochloride

BMY 7378 dihydrochloride is a 5-HT_1A partial agonist and high affinity α_1D adrenoceptor antagonist (K_i values are 2, 800 and 600 nM at cloned rat α_1D, rat α_1A and hamster α_1B receptors, respectively).

Technical Data for BMY 7378 dihydrochloride

M. Wt	458.42
Formula	C₂₂H₃₁N₃O₃.2HCl
Storage	Store at RT
CAS Number	21102-95-4
PubChem ID	24744861
InChi Key	HZRPUQURUAXOHB-UHFFFAOYSA-N
Smiles	O=C1CC4(CCCC4)CC(N1CCN(CC3)CCN3C2=CC=CC=C2OC)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for BMY 7378 dihydrochloride

References are publications that support the biological activity of the product.

Yang and Endoh Pharmacological evidence for β_1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br.J.Pharmacol 1997 PMID: 9422797
Piascik The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J.Pharmacol.Exp.Ther. 1995 PMID: 8531132
Sharp Further investigation of the in vivo pharmacological properties of the putative 5-HT_1A antagonist, BMY 7378. Eur.J.Pharmacol. 1990 PMID: 1970304
Gruel and Glaser The putative 5-HT_1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur.J.Pharmacol. 1992 PMID: 1535319

BMY 7378 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1006

Key Product Details

Biological Activity for BMY 7378 dihydrochloride

Technical Data for BMY 7378 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for BMY 7378 dihydrochloride

Product Documents for BMY 7378 dihydrochloride

COA

Certificate of Analysis

SDS

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