BMY 7378 dihydrochloride

Name: BMY 7378 dihydrochloride
Brand: Tocris Bioscience
SKU: 1006

Catalog # 1006

Citations (6)

COA / SDS

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Key Product Details

Description:	Selective α_1D antagonist
Chemical Name:	8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
Molecular Weight:	458.42

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Biological Activity

BMY 7378 dihydrochloride is a 5-HT_1A partial agonist and high affinity α_1D adrenoceptor antagonist (K_i values are 2, 800 and 600 nM at cloned rat α_1D, rat α_1A and hamster α_1B receptors, respectively).

Technical Data

M. Wt	458.42
Formula	C₂₂H₃₁N₃O₃.2HCl
Storage	Store at RT
CAS Number	21102-95-4
PubChem ID	24744861
InChi Key	HZRPUQURUAXOHB-UHFFFAOYSA-N
Smiles	O=C1CC4(CCCC4)CC(N1CCN(CC3)CCN3C2=CC=CC=C2OC)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 458.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.91 mL	21.81 mL
5 mM	0.44 mL	2.18 mL	4.36 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References

References are publications that support the biological activity of the product.

Yang and Endoh Pharmacological evidence for β_1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br.J.Pharmacol 1997 PMID: 9422797
Piascik The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J.Pharmacol.Exp.Ther. 1995 PMID: 8531132
Gruel and Glaser The putative 5-HT_1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur.J.Pharmacol. 1992 PMID: 1535319
Sharp Further investigation of the in vivo pharmacological properties of the putative 5-HT_1A antagonist, BMY 7378. Eur.J.Pharmacol. 1990 PMID: 1970304

Citations for BMY 7378 dihydrochloride (6)

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Citations are publications that use Bio-Techne products. Selected citations for BMY 7378 dihydrochloride include:

Gadgaard & Jensen (2020) Functional characterization of 5-HT_1A and 5-HT_1B serotonin receptor signaling through G-protein-activated inwardly rectifying K⁺ channels in a fluorescence-based membrane potential assay. Biochem Pharmacolg. 175
PMID: 32088264
Kahn et al. (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med. 8:511
PMID: 27138566
Grisanti et al. (2011) α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages. J Pharmacol Exp Ther. 338:648
PMID: 21571945
Lee et al. (2010) Characterisation of the expression of NMDA receptors in human astrocytes. PLoS One. 5:e14123
PMID: 21152063
Atkins et al. (2010) Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits. PLoS One. 5:e12612
PMID: 20830308
Song et al. (2010) Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxyt. release by ATP and phenylephrine. Am J Physiol Regul Integr Comp Physiol. 299:R1529
PMID: 20881098

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