BMY 45778

Name: BMY 45778
Brand: Tocris Bioscience
SKU: 1442

Tocris Bioscience, part of Bio-Techne | Catalog # 1442

COA / SDS

Non-prostanoid prostacyclin IP receptor partial agonist

Discontinued Product

1442 has been discontinued. View all Prostanoid Receptor Agonists products.

Key Product Details

Description:	Non-prostanoid prostacyclin IP receptor partial agonist
Chemical Name:	[3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic acid
Purity:	≥99% (HPLC)
Molecular Weight:	438.44

View Full Technical Details for BMY 45778

Technical Data
Citations

Biological Activity for BMY 45778

BMY 45778 is a non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP₁ prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC₅₀ = 27-35 nM).

Licensing Information

Sold with the permission of Bristol-Myers Squibb Company

Technical Data for BMY 45778

M. Wt	438.44
Formula	C₂₆H₁₈N₂O₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	152575-66-1
PubChem ID	127861
InChi Key	DSRSEEYZGWTODH-UHFFFAOYSA-N
Smiles	OC(=O)COC1=CC(=CC=C1)C1=C(N=CO1)C1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for BMY 45778

References are publications that support the biological activity of the product.

Seiler [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and ilo. binding. Prostaglandins 1997 PMID: 9068064
Rudd Non-prostanoid prostacyclin mimetics as neuronal stimulants in the rat: comparison of vagus nerve and NANC innervation of the colon. Br.J.Pharmacol. 2000 PMID: 10683203