Betaxolol hydrochloride

Name: Betaxolol hydrochloride
Brand: Tocris Bioscience
SKU: 0906

Tocris Bioscience a Bio-Techne Brand

Catalog # 0906

Citations (5)

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Key Product Details

Description:	Selective β₁ antagonist
Chemical Name:	1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	343.89

View Full Technical Details for Betaxolol hydrochloride

Biological Activity for Betaxolol hydrochloride

Betaxolol hydrochloride is a selective β₁-adrenoceptor antagonist.

Technical Data for Betaxolol hydrochloride

M. Wt	343.89
Formula	C₁₈H₂₉NO₃.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	63659-19-8
PubChem ID	107952
InChi Key	CHDPSNLJFOQTRK-UHFFFAOYSA-N
Smiles	Cl.CC(C)NCC(O)COC1=CC=C(CCOCC2CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Betaxolol hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	17.19	50

Preparing Stock Solutions for Betaxolol hydrochloride

The following data is based on the product molecular weight 343.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.82 mL	29.08 mL	58.16 mL
2.5 mM	1.16 mL	5.82 mL	11.63 mL
5 mM	0.58 mL	2.91 mL	5.82 mL
25 mM	0.12 mL	0.58 mL	1.16 mL

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References for Betaxolol hydrochloride

References are publications that support the biological activity of the product.

Setoguchi Inhibitory action of betaxolol, a β₁-selective adrenoceptor antagonist, on voltage-dependent calcium channels in guinea pig artery and vein. Br.J.Pharmacol. 1995 PMID: 7647977
Satoh The affinity of betaxolol, a β₁-adrenoceptor-selective blocking agent, for β-adrenoceptors in the bovine trachea and heart Br.J.Pharmacol. 1993 PMID: 8383566
Beresford and Heel Betaxolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in hypertension. Drugs 1986 PMID: 2866947

Citations for Betaxolol hydrochloride (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Betaxolol hydrochloride include:

Littmann et al. (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Cardiovasc Res. 355:183
PMID: 26306764
Meitzen et al. (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 116:984
PMID: 21143600
Schutsky et al. (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci. 31:14172
PMID: 21976502
Nobis et al. (2011) β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism. Biol Psychiatry. 69:1083
PMID: 21334600
Nackley et al. (2007) Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain. 128:199
PMID: 17084978

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Showing 1 - 5 of 5 citations Showing All

Product Documents for Betaxolol hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.