BD 1008 dihydrobromide

Name: BD 1008 dihydrobromide
Brand: Tocris Bioscience
SKU: 0511

Tocris Bioscience, part of Bio-Techne | Catalog # 0511

Citations (2)

COA / SDS

Potent, selective σ ligand

Discontinued Product

0511 has been discontinued. View all General Sigma Receptor Ligands products.

Key Product Details

Description:	Potent, selective σ ligand
Chemical Name:	N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine dihydrobromide
Molecular Weight:	463.08

View Full Technical Details for BD 1008 dihydrobromide

Technical Data
Citations

Biological Activity for BD 1008 dihydrobromide

Potent and selective σ-ligand (K_i against [³H]-(+)-3-PPP = 0.34 nM).

Technical Data for BD 1008 dihydrobromide

M. Wt	463.08
Formula	C₁₅H₂₂Cl₂N₂.2HBr
Storage	Store at -20°C
CAS Number	138356-09-9
PubChem ID	45073417
InChi Key	YTBUMHOSKIAYCZ-UHFFFAOYSA-N
Smiles	Br.Br.CN(CCN1CCCC1)CCC1=CC=C(Cl)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BD 1008 dihydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	23.15	50

Preparing Stock Solutions for BD 1008 dihydrobromide

The following data is based on the product molecular weight 463.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.32 mL	21.59 mL	43.19 mL
2.5 mM	0.86 mL	4.32 mL	8.64 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
25 mM	0.09 mL	0.43 mL	0.86 mL

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Reconstitution Calculator

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References for BD 1008 dihydrobromide

References are publications that support the biological activity of the product.

Monnet Differentiation of σ ligand-activated receptor subtypes that modulate NMDA-evoked [³H]-noradrenaline release in rat hippocampal slices. Br.J.Pharmacol. 1996 PMID: 8872358
Whittemore Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 1997 PMID: 9223571
De Costa Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines - structural requirements and binding affinity at the σ receptor. J.Med.Chem. 1992 PMID: 1310114