BD 1008 dihydrobromide

Name: BD 1008 dihydrobromide
Brand: tocris
SKU: 0511

Catalog # 0511

Citations (2)

Datasheet / COA / SDS

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Key Product Details

Description:	Potent, selective σ ligand
Chemical Name:	N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine dihydrobromide

View Full Technical Details for BD 1008 dihydrobromide

Technical Data
Citations (2) / Reviews

Biological Activity

Potent and selective σ-ligand (K_i against [³H]-(+)-3-PPP = 0.34 nM).

Technical Data

M. Wt	463.08
Formula	C₁₅H₂₂Cl₂N₂.2HBr
Storage	Store at -20°C
CAS Number	138356-09-9
PubChem ID	45073417
InChi Key	YTBUMHOSKIAYCZ-UHFFFAOYSA-N
Smiles	Br.Br.CN(CCN1CCCC1)CCC1=CC=C(Cl)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	23.15	50

Preparing Stock Solutions

The following data is based on the product molecular weight 463.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.32 mL	21.59 mL	43.19 mL
2.5 mM	0.86 mL	4.32 mL	8.64 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
25 mM	0.09 mL	0.43 mL	0.86 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

De Costa Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines - structural requirements and binding affinity at the σ receptor. J.Med.Chem. 1992 PMID: 1310114
Monnet Differentiation of σ ligand-activated receptor subtypes that modulate NMDA-evoked [³H]-noradrenaline release in rat hippocampal slices. Br.J.Pharmacol. 1996 PMID: 8872358
Whittemore Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 1997 PMID: 9223571

Showing 1-2 of 2 citations

Citations (2)

Citations are publications that use Bio-techne products. Selected citations for BD 1008 dihydrobromide include:

Hiranita et al. (2013) Stimulants as specific inducers of DA-independentσ agonist self-administration in rats. Neurochem Int. 347:42633
PMID: 23908387
Hiranita et al. (2011) Decreases in cocaine self-administration with dual inhibition of the DA transporter and σ receptors. J Pharmacol Exp Ther. 339:662
PMID: 21859929

BD 1008 dihydrobromide

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Key Product Details

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (2)

Product Datasheets

COA

Certificate of Analysis

SDS

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