BAY 87-2243

Name: BAY 87-2243
Brand: Tocris Bioscience
SKU: 6980

Tocris Bioscience, part of Bio-Techne | Catalog # 6980

Citations (3)

COA / SDS

Mitochondrial complex I inhibitor

Discontinued Product

6980 has been discontinued. View all Oxidative Phosphorylation Inhibitors products.

Key Product Details

Description:	Mitochondrial complex I inhibitor
Chemical Name:	1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine
Purity:	≥98% (HPLC)
Molecular Weight:	525.54

View Full Technical Details for BAY 87-2243

Technical Data
Citations

Biological Activity for BAY 87-2243

BAY 87-2243 is a mitochondrial complex I inhibitor. Exhibits no effect on mitochondrial complex III. Induces mitochondrial permeability transition pore (mPTP) opening, stimulates autophagosome formation and mitophagy, and increases ROS levels. Activates necroptotic and ferroptotic cell death. Also inhibits hypoxia-induced gene activation. Induces cell death in melanoma cell lines in vitro and exhibits antitumor activity in a mouse NSCLC xenograft model in vivo.

Compound Libraries for BAY 87-2243

BAY 87-2243 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BAY 87-2243

M. Wt	525.54
Formula	C₂₆H₂₆F₃N₇O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1227158-85-1
PubChem ID	67377767
InChi Key	CDJNNOJINJAXPV-UHFFFAOYSA-N
Smiles	CC1=CC(=NN1CC1=CC=NC(=C1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1=CC=C(OC(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for BAY 87-2243

References are publications that support the biological activity of the product.

Ellinghaus BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med. 2013 PMID: 24403227
Basit Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. Cell Death Dis. 2017 PMID: 28358377