B-HT 920

Name: B-HT 920
Brand: Tocris Bioscience
SKU: 2759

Tocris Bioscience a Bio-Techne Brand

Catalog # 2759

Citations (1)

COA / SDS

Discontinued Product

2759 has been discontinued. View all Dopamine D2 Receptor Agonists products.

Key Product Details

Description:	D₂ agonist; also α₂-adrenoceptor agonist and 5-HT₃ antagonist
Alternative Names:	Talipexole
Chemical Name:	5,6,7,8-Tetrahydro-6-(2-propen-1-yl)-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	282.23

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Biological Activity for B-HT 920

B-HT 920 is a dopamine D₂ receptor agonist, α₂-adrenoceptor agonist and 5-HT₃ receptor antagonist. Displays antiParkinsonian activity.

Technical Data for B-HT 920

M. Wt	282.23
Formula	C₁₀H₁₅N₃S.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	36085-73-1
PubChem ID	104870
InChi Key	DPQAXNSOFFYKDS-UHFFFAOYSA-N
Smiles	Cl.Cl.NC1=NC2=C(CCN(CC=C)CC2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for B-HT 920

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	28.22	100
	DMSO	28.22	100

Preparing Stock Solutions for B-HT 920

The following data is based on the product molecular weight 282.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.54 mL	17.72 mL	35.43 mL
5 mM	0.71 mL	3.54 mL	7.09 mL
10 mM	0.35 mL	1.77 mL	3.54 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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References for B-HT 920

References are publications that support the biological activity of the product.

Maina and Mathews A functional fast scan cyclic voltammetry assay to characterize DA D2 and D3 autoreceptors in the mouse striatum. ACS Chem.Neurosci. 2010 PMID: 20567609
Ricci and Taira Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen.Pharmacol. 1999 PMID: 9888250
Nishio 5-HT₃ receptor blocking properties of the antiParkinsonian agent, talipexole. Gen.Pharmacol. 1996 PMID: 8842679
Robertson In vivo comparisons of the effects of quinpirole and the putative presynaptic DArgic agonists B-HT 920 and SND 919 on striatal DA and acetylcholine release. J.Pharmacol.Exp.Ther. 1993 PMID: 8095550

Citations for B-HT 920 (1)

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Citations are publications that use Bio-Techne products. Selected citations for B-HT 920 include:

Otvos et al. (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Autophagy. 7:2336
PMID: 26114334

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