AZ 3451

Name: AZ 3451
Brand: Tocris Bioscience
SKU: 6806

Tocris Bioscience, part of Bio-Techne | Catalog # 6806

COA / SDS

Potent negative allosteric modulator of PAR2 receptors

Discontinued Product

6806 has been discontinued. View all Protease-Activated Receptor Antagonists products.

Key Product Details

Description:	Potent negative allosteric modulator of PAR₂ receptors
Chemical Name:	2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	571.46

View Full Technical Details for AZ 3451

Technical Data
Citations

Biological Activity for AZ 3451

AZ 3451 is a potent negative allosteric modulator of PAR₂ (IC₅₀ = 23 nM); binds to a remote allosteric site outside the helical bundle. Inhibits ERK phosphorylation in 1321N1 cells overexpressing wild-type human PAR₂. Highly lipophilic.

Compound Libraries for AZ 3451

AZ 3451 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ 3451

M. Wt	571.46
Formula	C₃₀H₂₇BrN₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2100284-59-9
PubChem ID	126961335
InChi Key	FJAOGFGHTPYADT-SFHVURJKSA-N
Smiles	C[C@H](N1C2=CC=C(C(NC3=CC=C(C#N)C=C3)=O)C=C2N=C1C4=C(C=C5OCOC5=C4)Br)C6CCCCC6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for AZ 3451

References are publications that support the biological activity of the product.

Cheng Structural insight into allosteric modulation of protease-activated receptor 2. Nature 2017 PMID: 28445455