ATPA

Name: ATPA
Brand: Tocris Bioscience
SKU: 1107

Catalog # 1107

Citations (7)

COA / SDS

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Key Product Details

Description:	Potent and selective GluK1 kainate agonist
Chemical Name:	(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	228.25

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Biological Activity

ATPA is a selective and potent GluK1 (formerly GluR5) kainate receptor agonist (K_i = 4.3 nM), inactive at GluK6 (formerly GluR6) (K_i > 1 mM) and only weakly active at AMPA receptors (GluA1-4) and the kainate receptors GluK5 (formerly KA-2) and GluK3 (formerly GluR7) (K_i values of 6 - 14 μM).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M. Wt	228.25
Formula	C₁₀H₁₆N₂O₄
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	140158-50-5
PubChem ID	2253
InChi Key	PIXJURSCCVBKRF-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=C(CC(N)C(O)=O)C(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	2.28	10 with gentle warming
	1eq. NaOH	4.57	20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 228.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	21.91 mL	109.53 mL	219.06 mL
1 mM	4.38 mL	21.91 mL	43.81 mL
2 mM	2.19 mL	10.95 mL	21.91 mL
10 mM	0.44 mL	2.19 mL	4.38 mL

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References

References are publications that support the biological activity of the product.

Moldrich Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures. Eur.J.Pharmacol. 1999 PMID: 10478637
Clarke A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 1997 PMID: 9335499
Matzen AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid. J.Med.Chem. 1997 PMID: 9046343

Citations for ATPA (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for ATPA include:

Langner et al. (2017) Kynurenic Acid Induces Impairment of Oligodendrocyte Viability: On the Role of Glutamatergic Mechanisms. Neurochem Res. 42:838
PMID: 27444613
Song et al. (2015) MinCyc does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice. Front Pediatr. 11:25
PMID: 25933605
Randall et al. (2011) Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro. Eur J Neurosci. 33:914
PMID: 21255131
Talpalar and Kiehn (2010) Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG. Front Neural Circuits. 4
PMID: 20844601
Dargan et al. (2009) ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology. 56:121
PMID: 18789344
Xu et al. (2006) Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Mol Pain. 2:29
PMID: 16948848
Liu et al. (2004) Astrocyte-mediated activation of neuronal kainate receptors. Mol Pain. 101:3172
PMID: 14766987

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