Atorvastatin hemicalcium salt

Name: Atorvastatin hemicalcium salt
Brand: Tocris Bioscience
SKU: 3776
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3776

(1)

Citations (18)

COA / SDS

Potent HMG-CoA reductase inhibitor

Discontinued Product

3776 has been discontinued. View all HMG-CoA Reductase Inhibitors products.

Key Product Details

Description:	Potent HMG-CoA reductase inhibitor
Alternative Names:	Lipitor
Chemical Name:	(R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
Purity:	≥99% (HPLC)
Molecular Weight:	577.67

View Full Technical Details for Atorvastatin hemicalcium salt

Technical Data
Citations / Reviews (1)

Biological Activity for Atorvastatin hemicalcium salt

Potent HMG-CoA reductase inhibitor (IC₅₀ = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Atorvastatin hemicalcium salt

M. Wt	577.67
Formula	C₃₃H₃₄FN₂O₅.½Ca
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	134523-03-8
PubChem ID	60822
InChi Key	FQCKMBLVYCEXJB-MNSAWQCASA-L
Smiles	[Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Atorvastatin hemicalcium salt

References are publications that support the biological activity of the product.

Turner Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 2007 PMID: 18049315
Vaughan Update on STAT: 2003. Circulation 2004 PMID: 15313959
Santodomingo-Garzon AtoVas inhibits inflammatory hypernociception. Br.J.Pharmacol. 2006 PMID: 16865092
Istvan Structural mechanism for statin inhibition of HMG-CoA reductase. Science 2001 PMID: 11349148