Arecaidine propargyl ester tosylate

Name: Arecaidine propargyl ester tosylate
Brand: Tocris Bioscience
SKU: 0383

Catalog # 0383

COA / SDS

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Key Product Details

Description:	Muscarinic agonist
Chemical Name:	N-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid propargyl ester tosylate
Molecular Weight:	351.42

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Biological Activity

Arecaidine propargyl ester tosylate is an a potent muscarinic receptor agonist. Shows some selectivity for cardiac versus ileal M₂ receptors.

Technical Data

M. Wt	351.42
Formula	C₁₀H₁₃NO₂.C₇H₈SO₃
Storage	Store at RT
CAS Number	147202-94-6
PubChem ID	6604936
InChi Key	LYHWIOMAWPVTPI-UHFFFAOYSA-N
Smiles	CC1=CC=C(C=C1)S(O)(=O)=O.CN1CCC=C(C1)C(=O)OCC#C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.23 mL	28.46 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Moser Structure-activity relationships of new analogues of arecaidine propargyl ester at muscarinic M₁ and M₂ receptor subtypes. Br.J.Pharmacol. 1989 PMID: 2924082
Barlow and Weston-Smith The relative potencies of some agonists at M₂ muscarinic receptors in guinea pig ileum, atria and bronchi. Br.J.Pharmacol. 1985 PMID: 3896364

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