Apigenin

Name: Apigenin
Brand: Tocris Bioscience
SKU: 1227

Tocris Bioscience, part of Bio-Techne | Catalog # 1227

Citations (11)

COA / SDS

Protein kinase inhibitor

Discontinued Product

1227 has been discontinued. View all Broad Spectrum Protein Kinase Inhibitors products.

Key Product Details

Description:	Protein kinase inhibitor
Chemical Name:	5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity:	≥97% (HPLC)
Molecular Weight:	270.2

View Full Technical Details for Apigenin

Technical Data
Citations

Biological Activity for Apigenin

Apigenin is a protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC₅₀ values are 59.44 and 31.15 μM at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.

Technical Data for Apigenin

M. Wt	270.2
Formula	C₁₅H₁₀O₅
Storage	Desiccate at +4°C
Purity	≥97% (HPLC)
CAS Number	520-36-5
PubChem ID	5280443
InChi Key	KZNIFHPLKGYRTM-UHFFFAOYSA-N
Smiles	OC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Apigenin

References are publications that support the biological activity of the product.

Sato Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem.Biophys.Res.Commun. 1994 PMID: 7980517
Lin Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J.Cell.Biochem.Suppl. 1997 PMID: 9589348
Jin Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress. Eur.J.Pharmacol. 2009 PMID: 19549516
Kuo and Yang Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem.Biophys.Res.Commun. 1995 PMID: 7626110
Choi Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells. J.Clin.Biochem.Nutr. 2009 PMID: 19430615

Apigenin

Tocris Bioscience, part of Bio-Techne | Catalog # 1227

Key Product Details

Biological Activity for Apigenin

Technical Data for Apigenin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Apigenin

Product Documents for Apigenin

COA

Certificate of Analysis

SDS

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