Aniracetam

Name: Aniracetam
Brand: Tocris Bioscience
SKU: 0867

Catalog # 0867

Citations (1)

COA / SDS

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Key Product Details

Description:	Inhibits desensitization; AMPA > kainate
Chemical Name:	1-(4-Methoxybenzoyl)-2-pyrrolidinone
Purity:	≥99% (HPLC)
Molecular Weight:	219.24

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Biological Activity

Aniracetam is a nootropic, with modulatory actions through allosteric potentiation of AMPA specific receptors, reduction of glutamate receptor desensitization and potentiation of metabotropic glutamate receptor activity. Anxiolytic following systemic administration.

Technical Data

M. Wt	219.24
Formula	C₁₂H₁₃NO₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	72432-10-1
PubChem ID	2196
InChi Key	ZXNRTKGTQJPIJK-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1)C(=O)N1CCCC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	5.48	25
	DMSO	21.92	100

Preparing Stock Solutions

The following data is based on the product molecular weight 219.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.56 mL	22.81 mL	45.61 mL
5 mM	0.91 mL	4.56 mL	9.12 mL
10 mM	0.46 mL	2.28 mL	4.56 mL
50 mM	0.09 mL	0.46 mL	0.91 mL

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References

References are publications that support the biological activity of the product.

Nakamura and Kurasawa Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur.J.Pharmacol. 2001 PMID: 11412837
Isaacson and Nicholl Aniracetam reduces glutamate receptor desensitisation and slows the decay of fast excitatory synaptic currents in the hippocampus. Proc.Natl.Acad.Sci.U.S.A. 1991 PMID: 1660156
Ito Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. J.Physiol. 1990 PMID: 1975272

Citations for Aniracetam (1)

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Citations are publications that use Bio-Techne products. Selected citations for Aniracetam include:

Moldavan and Allen (2010) Retinohypothalamic tract synapses in the rat suprachiasmatic nucleus demonstrate short-term synaptic plasticity. J Neurophysiol. 103:2390
PMID: 20220078

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