Aminopotentidine

Name: Aminopotentidine
Brand: tocris
SKU: 0721

Catalog # 0721

Datasheet / COA / SDS

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Bio-Techne Corporation

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$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	H₂ antagonist
Chemical Name:	4-Amino-N-[2-[[(cyanoamino)[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]imino]methyl]amino]ethyl]benzamide
Purity:	≥97% (HPLC)
Molecular Weight:	477.6

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Biological Activity

Aminopotentidine is a H₂ antagonist (K_B values are 220 and 280 nM at human and guinea pig H₂ receptors respectively) and precursor for the synthesis of the [¹²⁵I]-iodo derivative.

Technical Data

M. Wt	477.6
Formula	C₂₆H₃₅N₇O₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	140873-26-3
PubChem ID	164435
InChi Key	CICDSYWWNDGAGD-UHFFFAOYSA-N
Smiles	O=C(C3=CC=C(N)C=C3)NCCNC(NCCCOC1=CC(CN2CCCCC2)=CC=C1)=NC#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.76	100
	ethanol	47.76	100

Preparing Stock Solutions

The following data is based on the product molecular weight 477.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.47 mL	20.94 mL
5 mM	0.42 mL	2.09 mL	4.19 mL
10 mM	0.21 mL	1.05 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Hirschfield Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H₂ receptor. J.Med.Chem. 1992 PMID: 1613748
Ruat Reversible and irreversible labeling and autoradiographic localisation of the cerebral histamine H₂ receptor using [¹²⁵I]iodinated probes. Proc.Natl.Acad.Sci.USA 1990 PMID: 2308927
Xie Synthesis and pharmacological characterization of novel fluorescent histamine H₂-receptor ligands derived from aminopotentidine. Bioorg.Med.Chem.Lett. 2006 PMID: 16730977