Aminoguanidine hydrochloride

Name: Aminoguanidine hydrochloride
Brand: tocris
SKU: 0787

Catalog # 0787

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	Irreversible iNOS inhibitor
Molecular Weight:	110.55

View Full Technical Details for Aminoguanidine hydrochloride

Technical Data
Citations (1) / Reviews

Biological Activity

Irreversible inhibitor of iNOS that displays some selectivity over eNOS and nNOS. Exhibits antioxidant and radioprotective effects in vivo.

Technical Data

M. Wt	110.55
Formula	CH₆N₄.HCl
Storage	Store at RT
CAS Number	1937-19-5
PubChem ID	16017
InChi Key	UBDZFAGVPPMTIT-UHFFFAOYSA-N
Smiles	Cl.N=C(NN)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 110.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	9.05 mL	45.23 mL	90.46 mL
5 mM	1.81 mL	9.05 mL	18.09 mL
10 mM	0.90 mL	4.52 mL	9.05 mL
50 mM	0.18 mL	0.90 mL	1.81 mL

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References

References are publications that support the biological activity of the product.

Griffiths Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br.J.Pharmacol. 1993 PMID: 7507781
Huang Aminoguanidine alleviates radiation-induced small-bowel damage through its antioxidant effect. Int.J.Radiat.Oncol.Biol.Phys. 2009 PMID: 19362242
Laszlo Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. Eur.J.Pharmacol. 1995 PMID: 7536162
Moore and Handy Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 1997 PMID: 9226999

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Aminoguanidine hydrochloride include:

Jakubowska et al. (2016) Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biol.. 6:160149
PMID: 27488376

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Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

Aminoguanidine hydrochloride

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Key Product Details

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

SDS

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