Ambenonium dichloride

Name: Ambenonium dichloride
Brand: Tocris Bioscience
SKU: 0388

Tocris Bioscience, part of Bio-Techne | Catalog # 0388

Citations (9)

COA / SDS

Cholinesterase inhibitor

Discontinued Product

0388 has been discontinued. View all Cholinesterase Inhibitors products.

Key Product Details

Description:	Cholinesterase inhibitor
Chemical Name:	N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride
Purity:	≥99%
Molecular Weight:	608.48

View Full Technical Details for Ambenonium dichloride

Technical Data
Citations

Biological Activity for Ambenonium dichloride

Ambenonium dichloride is an extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC₅₀ values are 0.000698 and 8.20 μM at AChE and BChE respectively).

Technical Data for Ambenonium dichloride

M. Wt	608.48
Formula	C₂₈H₄₂Cl₄N₄O₂
Storage	Store at RT
Purity	≥99%
CAS Number	115-79-7
PubChem ID	8288
InChi Key	DXUUXWKFVDVHIK-UHFFFAOYSA-N
Smiles	[Cl-].[Cl-].CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=C(Cl)C=CC=C1)CC1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ambenonium dichloride

References are publications that support the biological activity of the product.

Web Affinity for benzoquinonium, and amben. derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 1965 PMID: 5833399
Hodge Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 1992 PMID: 1588924
Lands An investigation of the structure-activity correlations within a series of amben. analogs. J.Pharmacol.Exp.Ther. 1958 PMID: 13550066
Bolognesi Design, synthesis and biological evaluation of amben. derivatives as AChE inhibitors. Farmaco 2003 PMID: 13679187

Ambenonium dichloride

Tocris Bioscience, part of Bio-Techne | Catalog # 0388

Key Product Details

Biological Activity for Ambenonium dichloride

Technical Data for Ambenonium dichloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Ambenonium dichloride

Product Documents for Ambenonium dichloride

COA

Certificate of Analysis

SDS

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