Ambenonium dichloride

Name: Ambenonium dichloride
Brand: Tocris Bioscience
SKU: 0388

Catalog # 0388

Citations (2)

COA / SDS

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Key Product Details

Description:	Cholinesterase inhibitor
Chemical Name:	N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride
Purity:	≥99%
Molecular Weight:	608.48

View Full Technical Details for Ambenonium dichloride

Biological Activity

Ambenonium dichloride is an extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC₅₀ values are 0.000698 and 8.20 μM at AChE and BChE respectively).

Technical Data

M. Wt	608.48
Formula	C₂₈H₄₂Cl₄N₄O₂
Storage	Store at RT
Purity	≥99%
CAS Number	115-79-7
PubChem ID	8288
InChi Key	DXUUXWKFVDVHIK-UHFFFAOYSA-N
Smiles	[Cl-].[Cl-].CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=C(Cl)C=CC=C1)CC1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 608.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.22 mL	16.43 mL
5 mM	0.33 mL	1.64 mL	3.29 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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References

References are publications that support the biological activity of the product.

Bolognesi Design, synthesis and biological evaluation of amben. derivatives as AChE inhibitors. Farmaco 2003 PMID: 13679187
Hodge Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 1992 PMID: 1588924
Web Affinity for benzoquinonium, and amben. derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 1965 PMID: 5833399
Lands An investigation of the structure-activity correlations within a series of amben. analogs. J.Pharmacol.Exp.Ther. 1958 PMID: 13550066

Citations for Ambenonium dichloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for Ambenonium dichloride include:

Mamaligas et al. (2016) Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission Scientific Reports. 6:37834
PMID: 27886263
Shin et al. (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. Int J Mol Sci. 112:8124
PMID: 26080439

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