Ac9-25

Tocris Bioscience a Bio-Techne Brand

Catalog # 3231

COA / SDS

Discontinued Product

3231 has been discontinued. View all Formyl Peptide Receptor Ligands products.

Key Product Details

Description:	Annexin I N-terminal peptide; acts as a FPR1 ligand
Molecular Weight:	2183.35

View Full Technical Details for Ac9-25

Biological Activity for Ac9-25

Ac9-25 is a N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.

Technical Data for Ac9-25

M. Wt	2183.35
Formula	C₉₉H₁₄₃N₂₃O₃₃
Single Letter Sequence	QAWFIENEEQEYVQTVK (Modifications: Gln-1 = N-terminal amide)
Storage	Desiccate at -20°C
CAS Number	284040-76-2
PubChem ID	90488817
InChi Key	VWAGQOJTUDBVPD-ZONPJGGESA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ac9-25

Solubility

Soluble to 1mg/ml in 20% acetonitrile / water

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References for Ac9-25

References are publications that support the biological activity of the product.

Rabiert The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview. Biochimie 2007 PMID: 17428601
Karlsson Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol.
Walther A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol.Cell 2000 PMID: 10882119

Citations for Ac9-25

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Ac9-25

Tocris Bioscience a Bio-Techne Brand

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Biological Activity for Ac9-25

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References for Ac9-25

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Product Documents for Ac9-25

COA

Certificate of Analysis

SDS

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