α-Conotoxin PIA

Name: α -Conotoxin PIA
Brand: Tocris Bioscience
SKU: 3121

Tocris Bioscience a Bio-Techne Brand

Catalog # 3121

Citations (1)

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Key Product Details

Description:	Selective antagonist of α6-containing nAChRs
Molecular Weight:	1981.3

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Biological Activity for α-Conotoxin PIA

α-Conotoxin PIA is a selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC₅₀ values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).

Licensing Information

Sold under license from University of Utah

Technical Data for α-Conotoxin PIA

M. Wt	1981.3
Formula	C₇₉H₁₂₅N₂₇O₂₅S₄
Single Letter Sequence	RDPCCSNPVCTVHNPQIC (Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)
Storage	Store at -20°C
CAS Number	669050-68-4
PubChem ID	90488800
InChi Key	WINQUAHGULGZED-WAIIABLISA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H](NC(=O)C(NC2=O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(N)=O)NC1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-Conotoxin PIA

Solubility

Soluble to 2mg/ml in water

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References for α-Conotoxin PIA

References are publications that support the biological activity of the product.

Azam and McIntosh Effect of novel α-Conotoxins on nicotine-stimulated [³H]DA release from rat striatal synaptosomes. J.Pharmacol.Exp.Ther. 2005 PMID: 15316087
Chi Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors. Biochem.Biophys.Res.Comms.
Dowell α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 2003 PMID: 13679412

Citations for α-Conotoxin PIA (1)

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Citations are publications that use Bio-Techne products. Selected citations for α-Conotoxin PIA include:

Garção et al. (2013) Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum. Br J Pharmacol. 169:1600
PMID: 23638679

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Product Documents for α-Conotoxin PIA

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.